Inhibition of pathogenic bacterial carbonic anhydrases by monothiocarbamates

Simone Giovannuzzia Neurofarba Department, Pharmaceutical and Nutraceutical Section, University of Florence, Sesto Fiorentino (FI), ItalyView further author information

Anil Kumar Marapakab Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, IN, USAView further author information

Nader S. Abutalebc Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA;d Center for One Health Research, Virginia Polytechnic Institute and State University, Blacksburg, VA, USAView further author information

Fabrizio Cartaa Neurofarba Department, Pharmaceutical and Nutraceutical Section, University of Florence, Sesto Fiorentino (FI), ItalyView further author information

Hsin-Wen Liangc Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA;d Center for One Health Research, Virginia Polytechnic Institute and State University, Blacksburg, VA, USAView further author information

Alessio Nocentinia Neurofarba Department, Pharmaceutical and Nutraceutical Section, University of Florence, Sesto Fiorentino (FI), ItalyView further author information

Luigi Pisanoe Section of Dermatology, Health Sciences Department, University of Florence, Florence, ItalyView further author information

Mohamed N. Seleemc Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA;d Center for One Health Research, Virginia Polytechnic Institute and State University, Blacksburg, VA, USAView further author information

Daniel P. Flahertyb Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, IN, USA;f Purdue Institute for Drug Discovery, West Lafayette, IN, USA;g Purdue Institute of Inflammation, Immunology and Infectious Disease, West Lafayette, IN, USACorrespondence[email protected]

https://orcid.org/0000-0002-8305-0606 View further author information

Claudiu T. Supurana Neurofarba Department, Pharmaceutical and Nutraceutical Section, University of Florence, Sesto Fiorentino (FI), ItalyCorrespondence[email protected]

https://orcid.org/0000-0003-4262-0323 View further author information

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Inhibition of pathogenic bacterial carbonic anhydrases by monothiocarbamates

Table 1. Inhibition data of hCA I and II and bacterial α-NgCA, α-EfCA and γ-EfCA, using AAZ as a standard drug, by a stopped-flow CO₂ hydrase assayCitation²².

Table 2. MICs (µg/mL) of MTCs 1, 6, 9, 12 and 13 against Neisseria gonorrhoeae clinical isolates.

Table 3. MICs (µg/mL) of MTCs 1, 6, 9, 12 and 13 against VRE strains.

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Inhibition of pathogenic bacterial carbonic anhydrases by monothiocarbamates

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Table 1. Inhibition data of hCA I and II and bacterial α-NgCA, α-EfCA and γ-EfCA, using AAZ as a standard drug, by a stopped-flow CO2 hydrase assayCitation22.

Table 2. MICs (µg/mL) of MTCs 1, 6, 9, 12 and 13 against Neisseria gonorrhoeae clinical isolates.

Table 3. MICs (µg/mL) of MTCs 1, 6, 9, 12 and 13 against VRE strains.

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Table 1. Inhibition data of hCA I and II and bacterial α-NgCA, α-EfCA and γ-EfCA, using AAZ as a standard drug, by a stopped-flow CO₂ hydrase assayCitation²².