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Review

The risks of using allogeneic cell lines for vaccine production: the example of Bovine Neonatal Pancytopenia

ORCID Icon & ORCID Icon
Pages 65-71 | Received 27 Jul 2016, Accepted 14 Oct 2016, Published online: 31 Oct 2016

Figures & data

Figure 1. Histological findings from femoral bone marrow from: (a) a field case of BNP euthanized at approximately 3 weeks old, showing almost total loss of hematopoietic cells and their replacement by erythrocytes and proteinaceous fluid and (b) an unaffected healthy calf, showing normal high cellularity with little fatty stromal tissue apparent. Haematoxylin and Eosin. Bars = 100 µm. (reproduced with permission from BMJ Publishing Group Limited. Idiopathic bovine neonatal pancytopenia in a Scottish beef herd [Citation2]).

Figure 1. Histological findings from femoral bone marrow from: (a) a field case of BNP euthanized at approximately 3 weeks old, showing almost total loss of hematopoietic cells and their replacement by erythrocytes and proteinaceous fluid and (b) an unaffected healthy calf, showing normal high cellularity with little fatty stromal tissue apparent. Haematoxylin and Eosin. Bars = 100 µm. (reproduced with permission from BMJ Publishing Group Limited. Idiopathic bovine neonatal pancytopenia in a Scottish beef herd [Citation2]).

Figure 2. Diagram illustrating the multifactorial pathogenesis of BNP.

Figure 2. Diagram illustrating the multifactorial pathogenesis of BNP.