Figures & data
Figure 1. Crystal structure of the PfAMA1 molecule. High (>10%) and low (1–10%) frequency polymorphic residues are indicated in red and blue, respectively. The part in grey (domain III) is modelled on the PvAMA1 molecule, in white the original PfAMA1 crystal structure is depicted. Figure from Faber et al. PLoS One 2015 [Citation13]. Full color available online.
![Figure 1. Crystal structure of the PfAMA1 molecule. High (>10%) and low (1–10%) frequency polymorphic residues are indicated in red and blue, respectively. The part in grey (domain III) is modelled on the PvAMA1 molecule, in white the original PfAMA1 crystal structure is depicted. Figure from Faber et al. PLoS One 2015 [Citation13]. Full color available online.](/cms/asset/701fe82d-5719-4f0c-9e17-0346e0487eef/ierv_a_1411198_f0001_oc.jpg)
Figure 2. Two dimensional (2D) genetic map of P. falciparum AMA1 diversity. Geographical origin of isolate indicated in colour: Green: West Africa, Purple: East Africa, White: South Africa, Red: South East Asia, Turquoise: South America. Several isolates are indicated by name. AMA1 DiCo proteins [Citation16] are presented as orange symbols with D1, D2 and D3 indicating DiCo 1 to 3. Gridlines indicate 5 amino acid differences. The distances are compressed in a two-dimensional space which does not accurately represent actual distances. An annotated 3D genetic map is provided online [Citation17]. The Genbank accession codes for the sequences used for the map are provided in supplementary Table 1. Full color available online
![Figure 2. Two dimensional (2D) genetic map of P. falciparum AMA1 diversity. Geographical origin of isolate indicated in colour: Green: West Africa, Purple: East Africa, White: South Africa, Red: South East Asia, Turquoise: South America. Several isolates are indicated by name. AMA1 DiCo proteins [Citation16] are presented as orange symbols with D1, D2 and D3 indicating DiCo 1 to 3. Gridlines indicate 5 amino acid differences. The distances are compressed in a two-dimensional space which does not accurately represent actual distances. An annotated 3D genetic map is provided online [Citation17]. The Genbank accession codes for the sequences used for the map are provided in supplementary Table 1. Full color available online](/cms/asset/d51dde8c-6389-43d1-b509-7a0b1e2b110f/ierv_a_1411198_f0002_oc.jpg)
Figure 3. Two dimensional (2D) Genetic map of influenza H1 Haemagglutinin amino acids 1 through 328. Colours indicate year of isolation: dark green 1918, purple 1934–1946, turquoise 1947–1957, red 1968–1976, light brown 1977–1986, dark brown 1987–1996, light green 1997–2007, blue 2008, orange 2009, dark grey 2010–2012. The strains used in Carter et al. [Citation41] are shown as + signs, blue = historical H1N1, red = modern H1N1 and green = H1N1pdm challenge strain. Gridlines indicate 5 amino acid differences. The distances are compressed in a two-dimensional space which does not accurately represent actual distances. An annotated 3D genetic map is provided online [Citation42]. The Genbank accession codes for the sequences used for the map are provided in supplementary Table 2. Full color available online.
![Figure 3. Two dimensional (2D) Genetic map of influenza H1 Haemagglutinin amino acids 1 through 328. Colours indicate year of isolation: dark green 1918, purple 1934–1946, turquoise 1947–1957, red 1968–1976, light brown 1977–1986, dark brown 1987–1996, light green 1997–2007, blue 2008, orange 2009, dark grey 2010–2012. The strains used in Carter et al. [Citation41] are shown as + signs, blue = historical H1N1, red = modern H1N1 and green = H1N1pdm challenge strain. Gridlines indicate 5 amino acid differences. The distances are compressed in a two-dimensional space which does not accurately represent actual distances. An annotated 3D genetic map is provided online [Citation42]. The Genbank accession codes for the sequences used for the map are provided in supplementary Table 2. Full color available online.](/cms/asset/8e60a0fa-71aa-4d9e-bcd4-47861cfe2fd2/ierv_a_1411198_f0003_oc.jpg)
Figure 4. Two dimensional (2D) Genetic map of dengue envelope protein. Dengue serotypes are indicated in colour: Green Dengue 1; Purple Dengue 2; Turquoise Dengue 3; Red Dengue 4. Gridlines indicate 5 amino acid differences. The distances are compressed in a two-dimensional space which does not accurately represent actual distances. An annotated 3D genetic map is provided online [Citation52]. The Genbank accession codes for the sequences used for the map are provided in supplementary Table 3. Full color available online.
![Figure 4. Two dimensional (2D) Genetic map of dengue envelope protein. Dengue serotypes are indicated in colour: Green Dengue 1; Purple Dengue 2; Turquoise Dengue 3; Red Dengue 4. Gridlines indicate 5 amino acid differences. The distances are compressed in a two-dimensional space which does not accurately represent actual distances. An annotated 3D genetic map is provided online [Citation52]. The Genbank accession codes for the sequences used for the map are provided in supplementary Table 3. Full color available online.](/cms/asset/8fc3ca41-54ba-4a46-8163-1ed4858e83d1/ierv_a_1411198_f0004_oc.jpg)
