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Review

Budget impact analysis of introducing a non-reconstituted, hexavalent vaccine for pediatric immunization in the United Kingdom

, ORCID Icon, , ORCID Icon, , , , & show all
Pages 1167-1175 | Received 30 Aug 2019, Accepted 06 Jan 2021, Published online: 27 Jan 2021

Figures & data

Figure 1. Schematic overview of the budget impact model structure. To provide an overview of the BIM as a whole, Hib treatment cost calculations are shown in grayed tones, because of its inapplicability to the UK setting. (Note: this figure is only used to visualize the connections between user-inputs, model calculations, and model outcomes and that the sizes of the figure parts are not representative for the impact on the model costs)

Figure 1. Schematic overview of the budget impact model structure. To provide an overview of the BIM as a whole, Hib treatment cost calculations are shown in grayed tones, because of its inapplicability to the UK setting. (Note: this figure is only used to visualize the connections between user-inputs, model calculations, and model outcomes and that the sizes of the figure parts are not representative for the impact on the model costs)

Table 1. Model settings and population inputs

Table 2. Cost inputs

Table 3. Resource use inputs

Figure 2. Annual budget impact per cost category (future vs. baseline market share scenario). Only three categories (vaccine costs – red, direct HCP vaccination costs – gray, and direct NSI costs – light blue) contributed to the cost-savings, the others were zero

Figure 2. Annual budget impact per cost category (future vs. baseline market share scenario). Only three categories (vaccine costs – red, direct HCP vaccination costs – gray, and direct NSI costs – light blue) contributed to the cost-savings, the others were zero

Figure 3. Deterministic sensitivity analysis on total budget impact

Figure 3. Deterministic sensitivity analysis on total budget impact

Figure 4. Boxplots of the probabilistic sensitivity analysis per cost category and total budget impact

Figure 4. Boxplots of the probabilistic sensitivity analysis per cost category and total budget impact

Table A1. Annual vaccine cost per cost-category

Table A2. Annual budget impact per cost-category