4,133
Views
6
CrossRef citations to date
0
Altmetric
Original Research

Reactogenicity and immunogenicity of BNT162b2 or mRNA-1273 COVID-19 booster vaccinations after two doses of BNT162b2 among healthcare workers in Japan: a prospective observational study

ORCID Icon, , , , , & show all
Pages 1319-1329 | Received 13 May 2022, Accepted 21 Jun 2022, Published online: 04 Jul 2022

Figures & data

Table 1. Demographics and characteristics of subjects receiving BNT162b2 and mRNA-1273.

Figure 1. Comparison of anti-Spike IgG titer level at baseline (before 3rd vaccination) and Day 28 after 3rd vaccination. BNT162b2: cohort with homologous BNT162b2 prim and BNT162b2 boost vaccine. mRNA-1273: cohort with heterologous BNT162b2 prime + mRNA-1273 booster.

Figure 1. Comparison of anti-Spike IgG titer level at baseline (before 3rd vaccination) and Day 28 after 3rd vaccination. BNT162b2: cohort with homologous BNT162b2 prim and BNT162b2 boost vaccine. mRNA-1273: cohort with heterologous BNT162b2 prime + mRNA-1273 booster.

Figure 2. Distribution of anti-Spike IgG titer level at baseline (before 3rd vaccination) and Day 28 after 3rd vaccination by age groups (a) and sex (b). BNT162b2: cohort with homologous BNT162b2 prim and BNT162b2 boost vaccine. mRNA-1273: cohort with heterologous BNT162b2 prime + mRNA-1273 booster.

Figure 2. Distribution of anti-Spike IgG titer level at baseline (before 3rd vaccination) and Day 28 after 3rd vaccination by age groups (a) and sex (b). BNT162b2: cohort with homologous BNT162b2 prim and BNT162b2 boost vaccine. mRNA-1273: cohort with heterologous BNT162b2 prime + mRNA-1273 booster.

Table 2. Anti-Spike IgG at baseline and day 28 after 3rd vaccination by vaccine type, age, and sex.

Table 3. Common adverse reactions during the first 8 days after 2nd and 3rd vaccinations.

Figure 3. Distribution of self-reported adverse reactions during the first 8 days after vaccination (Day 0–7) by severity of the adverse reactions. The adverse reactions were categorized into (a) Injection-site reactions, or (b) Systemic reactions. Severity of adverse reaction were stratified into mild, moderate, or severe. Fever was stratified as ≥37.5°C and ≥38.0°C. Date of injection was defined as Day 0.

Figure 3. Distribution of self-reported adverse reactions during the first 8 days after vaccination (Day 0–7) by severity of the adverse reactions. The adverse reactions were categorized into (a) Injection-site reactions, or (b) Systemic reactions. Severity of adverse reaction were stratified into mild, moderate, or severe. Fever was stratified as ≥37.5°C and ≥38.0°C. Date of injection was defined as Day 0.

Figure 4. Self-reported adverse reactions during the first 8 days after 3rd vaccination, by age groups and sex. The adverse reactions were categorized into (a) Injection-site reactions, or (b) Systemic reactions.

Figure 4. Self-reported adverse reactions during the first 8 days after 3rd vaccination, by age groups and sex. The adverse reactions were categorized into (a) Injection-site reactions, or (b) Systemic reactions.
Supplemental material

Supplemental Material

Download MS Word (353 KB)

Data availability statement

The datasets generated during and/or analysed during the current study are not publicly available due to patient confidentiality, but the derived data supporting the findings of this current study are available from the corresponding author Prof. Ito and Prof. Tobita on reasonable request.