A comparison study of the 0.1% tretinoin cream versus fractional microneedle radiofrequency combination with fractional CO₂ laser for the treatment of striae alba in Indonesian patients

Figures & data

Table 1. Baseline characteristic

	0.1% tretinoin cream	FMR + fractional CO2 laser
Mean age (years ± SD) Clinical SA lesion	38.3 ± 9.3	36.7 ± 6.5
Length (mean ± SD)	67.1 ± 41.2	45.0 ± 26.3
Width (mean ± SD)	5.2 ± 0.8	4.7 ± 2.0
Collagen area	32.4 ± 7.5	41.2 ± 8.8

FMR: ractional microneedle radiofrequency; SD: standard deviation; SA: striae albae

Table 2. Comparison before and after therapy

		0,1% tretinoin cream (mean ± SD)	FMR + fractional CO2 laser (mean ± SD)
Length	Baseline	67.1 ± 41.2	45.0 ± 26.3
	3 months evaluation	67.1 ± 41.2	42.1 ± 25.4
Width	Baseline	5.2 ± 0.8	4.7 ± 2.0
	3 months evaluation	5.2 ± 0.8	4.3 ± 21
Collagen area	Baseline	32.4 ± 7.5	41.2 ± 8.8
	3 months evaluation	83.5 ± 10.4	84.1 ± 5.1

FMR: ractional microneedle radiofrequency; SD: standard deviation

Figure 1. Clinical SA lesions in study subjects in 0.1% tretinoin single-therapy, pre-therapy (A) and post-therapy (B)

Figure 2. Clinical SA lesions in study subjects in the combination therapy group FMR + fractional CO₂ laser, pre therapy (A) and post therapy (B)

Figure 3. Histopathology of the percentage area of collagen (100x magnification) in the study subjects in the 0.1% tretinoin cream group, pre therapy (A) and post therapy (B). Yellow arrows indicate an increase in the amount of collagen

Figure 4. Histopathology of the percentage area of collagen (100x magnification) in the study subjects in the combination therapy group FMR + fractional CO₂ laser, pre therapy (A) and post therapy (B). Yellow arrows indicate an increase in the amount of collagen