Maternal serum concentrations of the chemokine CXCL10/IP-10 are elevated in acute pyelonephritis during pregnancy

Figures & data

Figure 1. Maternal serum concentrations of CXCL10/IP-10 in patients with normal pregnancies and those with pyelonephritis. The median serum concentration of CXCL10/IP-10 in pregnant patients with pyelonephritis was significantly higher than in normal pregnant women (median 318.5 pg/mL, range 78.8–2459.2 vs. median 116.1 pg/mL, range 40.7–1314.3, respectively; p < 0.001).

Table I.  Clinical and obstetrical characteristics of the study groups

	Normal pregnancy (N = 89)	Pyelonephritis (N = 41)	p
Maternal age (years)	23 (17–34)	22 (17–41)	NS
Nulliparity	21.3 (19/89)	19.5 (8/41)	NS
Smoking	20.5 (17/83)	21.4 (6/28)	NS
Gestational age at blood draw (weeks)	31.1 (19.4–38.3)	31.2 (17–41.9)	NS
Gestational age at delivery (weeks)	39.6 (37–42)	39.1 (28.7–42.7)	NS
Birth weight (g)	3342 (2550–4050)	3140 (1080–4090)	0.02

Values are expressed as percentage (number) or median (range). NS: not significant.

Figure 2. Maternal serum concentrations of CXCL10/IP-10 in patients with pyelonephritis. No significant differences in maternal median serum concentrations of CXCL10/IP-10 were observed between patients with positive and negative blood cultures (median 362.6 pg/mL, range 100.2–2459.2 vs. median 298.9 pg/mL, range 108.5–1148.7, respectively; p = 0.3).