The value of serum pro-oxidant/antioxidant balance in the assessment of asphyxia in term neonates

Figures & data

Table 1. Clinical characteristics of asphyxiated newborns with normal and abnormal outcome.

Group variables	Asphyxiated newborns with normal outcomes (n = 47, 52.2%)	Asphyxiated newborns with abnormal outcomes (n = 43, 47.8%)	p value (t-test)
PAB (HK)	9.23 ± 17.11	41.30 ± 48.27	p < 0.0001
Birth weight (gram)	499.04 ± 2796.81	684.05 ± 2818.13	0.869
First minute Apgar score	1.81 ± 5.10	1.58 ± 4.54	0.125
Fifth minute Apgar score	1.61 ± 7.71	1.68 ± 6.38	p < 0.0001
Duration of IPPV (hour)	85.09 ± 54.85	63.03 ± 76.06	0.017
WBC	5435.30 ± 11 402.64	19 142.73 ± 18 792.09	0.033
Neutrophils (percentage)	18.47 ± 52.35	17.80 ± 51.15	0.78
Lymphocytes (percentage)	18.16 ± 45.20	32.14 ± 52.39	0.237
PLT**	62 116.39 ± 182 583.33	139 778.37 ± 227 017.64	0.258
pH1*	0.08 ± 7.24	0.11 ± 7.13	p < 0.0001
BE1*	5.10 ± −10.41	6.88 ± −11.62	0.399
HCO3a*	2.23 ± 17.00	5.03 ± 14.26	0.101

Data are presented as mean ± SD. PAB: pro-oxidant to antioxidant; IPPV: intermittent positive pressure ventilation; WBC: white blood cell; PLT: platelet.

* Samples were taken within the first hour of life.

** Samples were obtained 24 h after birth.

Table 2. Comparison of maternal and neonatal parameters between the two groups of asphyxiated infants with normal and abnormal outcomes unite: n (%).

Group variables	Asphyxiated newborns with normal outcomes (n = 47, 52.2%)	Asphyxiated newborns with abnormal outcomes (n = 43, 47.8%)	p value (chi-square)
Degree of HIE			p < 0.0001
Without HIE	13(32.5)	1 (2.38)
HIE Grade I	24 (60)	7 (16.66)
HIE Grade II	3 (7.5)	23 (54.76)
HIE Grade III	0 (0)	11 (26.19)
Developmental delay severity			p < 0.0001
Normal	47 (100)	0 (0)
Mild developmental delay	0 (0)	13 (14.4)
Moderate developmental delay	0 (0)	7 (7.8)
Severe developmental delay	0 (0)	11 (12.2)
Death	0 (0)	12 (13.3)
Sex
Male	25 (54.34)	27 (65.85)	0.275
Female	21 (45.65)	14 (34.14)
Method of delivery
Vaginal	12 (26.66)	16 (41.02)	0.164
Cesarean	33(73.33)	23 (58.97)

Figure 1. ROC curve for HIE, PAB, and other indicators for determining outcomes in asphyxiated babies.

Table 3. Comparison the combination of PAB, severity of HIE, first hour pH, and fifth minute Apgar score in order to determine the prognosis of developmental delay.

Diagnostic methods	−2 log likelihood	Cox & Snell R^2	Nagelkerke R^2	Predicted percentage correct
PAB + HIE grade + fifth minute Apgar	21.541	0.663	0.884	94.4
PAB + HIE grade	23.151	0.668	0.891	95.2
HIE grade + fifth minute Apgar	39.117	0.57	0.759	88.9
PAB + pH + fifth minute Apgar	39.676	0.587	0.784	88.8
HIE grade + fifth minute Apgar	60.991	0.459	0.612	87.2
PAB + fifth minute Apgar	55.92	0.527	0.669	83.9
PAB	68.77	0.462	0.617	81.1
HIE grade	58.91	0.487	0.649	86.6