Genetic heterogeneity of platelet glycoproteins Ia and IIIa and the risk of spontaneous miscarriages

Abstract

Objective: The aim of this study was to investigate the association between the genetic heterogeneity of platelet glycoproteins Ia (GpIa-C807T) and IIIa (GpIIIa-PlA1/PlA2) and spontaneous abortions.

Study design: Two hundred and twenty two women with a history of unexplained spontaneous miscarriages and no successful pregnancy, and 60 fertile women serving as controls were genotyped for the GpIa-C807T and GpIIIa-PlA1/PlA2 polymorphisms by pyrosequencing.

Results: In comparison with the common alleles homozygotes, GpIa-807T and GpIIIa-PlA2 carriers had an increased risk of fetal loss (OR = 3.36, 95%CI: 1.85–6.11, p < 0.001, and OR = 2.58, 95%CI: 1.30–5.13, p = 0.006, respectively). For subjects who were combined carriers of the GpIa-807T and GpIIIa-PlA2 alleles, the risk increased further (OR = 9.13, 95%CI: 2.99–27.82, p < 0.001). The above ORs were highest for women who were younger than 30 years of age.

Conclusions: The GpIa-C807T and GpIIIa-PlA1/PlA2 polymorphisms and more pronouncedly their combination are associated with increased risk of spontaneous abortions. The correlations were stronger for younger patients. Our results indicate that GpIa-807T and GpIIIa-PlA2 are susceptibility alleles for fetal loss in the Greek population.

Keywords:

• Miscarriage
• GpIa
• GpIIIa
• integrin alpha2
• integrin beta3
• thrombophilia
• platelet glycoproteins
• polymorphisms

Declaration of interest

The authors report no declaration of interest