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The Journal of Maternal-Fetal & Neonatal Medicine Volume 32, 2019 - Issue 14
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Original Article

Is the body composition development in premature infants associated with a distinctive nuclear magnetic resonance metabolomic profiling of urine?

Daniela MorniroliNICU, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca` Granda Ospedale Maggiore Policlinico, Universita` degli Studi di Milano, Milano, Italy; ORCID Iconhttp://orcid.org/0000-0003-4616-5081
ORCID Icon,
Angelica DessìNeonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, Azienda Ospedaliera Universitaria, University of Cagliari, Cagliari, Italy; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-1154-2118
ORCID Icon,
Maria Lorella GiannìNICU, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca` Granda Ospedale Maggiore Policlinico, Universita` degli Studi di Milano, Milano, Italy; ORCID Iconhttp://orcid.org/0000-0003-3901-9131
ORCID Icon,
Paola RoggeroNICU, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca` Granda Ospedale Maggiore Policlinico, Universita` degli Studi di Milano, Milano, Italy; ORCID Iconhttp://orcid.org/0000-0003-2667-4620
ORCID Icon,
Antonio NotoNeonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, Azienda Ospedaliera Universitaria, University of Cagliari, Cagliari, Italy; ORCID Iconhttp://orcid.org/0000-0003-3538-0050
ORCID Icon,
Luigi AtzoriDepartment of Biomedical Sciences, University of Cagliari, Cagliari, ItalyORCID Iconhttp://orcid.org/0000-0002-0606-4959
ORCID Icon,
Milena LussuDepartment of Biomedical Sciences, University of Cagliari, Cagliari, ItalyORCID Iconhttp://orcid.org/0000-0002-7824-692X
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Vassilios FanosNeonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, Azienda Ospedaliera Universitaria, University of Cagliari, Cagliari, Italy; ORCID Iconhttp://orcid.org/0000-0003-2617-2890
ORCID Icon &
Fabio MoscaNICU, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca` Granda Ospedale Maggiore Policlinico, Universita` degli Studi di Milano, Milano, Italy; ORCID Iconhttp://orcid.org/0000-0001-6477-0299
ORCID Icon show all
Pages 2310-2318 | Received 10 Oct 2017, Accepted 21 Jan 2018, Published online: 15 Feb 2018
 
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Abstract

Objective: Preterm infants’ body composition at term-corrected age differs from that of term infants but appears to be similar at the age of 3 months. The aim of this study was to compare the metabolomic pattern of preterm infants at term and at 3 months with that of term infants and to determine its association with body composition development.

Method: We designed a pilot study. Growth and body composition were evaluated by an air displacement plethysmography system in 13 preterm infants and seven term newborns at term and at 3 months of corrected age. Urine samples were collected at the same time points and analysed by nuclear magnetic resonance.

Results: At term-corrected age, preterm infants showed a higher fat mass percentage compared with that of term newborns, whereas at 3 months of corrected age, the body composition parameters were similar between the groups. At the first time point, nuclear magnetic resonance analysis showed a urinary increase in choline/phosphocholine, betaine and glucose in preterm infants. At the second time point, the preterm group exhibited a urinary increase in choline/phosphocholine and a decrease in betaine.

Conclusions: The increased urinary excretion of choline, a betaine precursor, could reflect a potential altered metabolism in preterm infants.

Disclosure statement

The authors report no conflicts of interest.

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