Proteomic signatures predict preeclampsia in individual cohorts but not across cohorts – implications for clinical biomarker studies

Figures & data

Table 1. Patient and pregnancy data.

	Stanford cohort		Detroit cohort
Demographics	Preeclampsia (n = 18)	Controls (n = 18)	Preeclampsia (n = 76)	Controls (n = 90)
Age (years)	32.0 [27.3–37.5]	30.0 [29.0–33.5]	22.0 [21.0–29.0]	24.0 [21.0–27.8]
Body mass index (kg/m^2)	27.9 [22.3–31.3]	22.3 [19.9–23.7]	30.0 [24.8.0–36.2]	26.5 [22.8–33.2]
Race
African American	1	0	72	84
Asian	2	0	0	0
Caucasian	14	18	4	6
Unknown	1	0	0	0
Pregnancy
Gravity	2 [1–2]	2 [1–3]	2 [1–4]	3 [2–5]
Parity (nulliparity)	7	8	32	26
Preeclampsia (mild/severe)
Early preeclampsia	3/2
Late preeclampsia	5/8		48/28
Gestational age at delivery
Early preeclampsia	31.3 [30.1–32.1]
Late preeclampsia	38.3 [37.1–39.6]		38.7 [37.7–39.4]
All		39.8 [39.1–40.8]		39.4 [39.0–40.4]

Reported are the median and interquartile range or absolute numbers.

Figure 1. Highest-ranking proteins associated with PE differ between cohorts. (A) All 1116 proteins included in the analysis are plotted according to their respective p value when comparing women with PE to women with uncomplicated pregnancies in the Stanford (x-axis) and the Detroit (y-axis) cohorts. The highest-ranking proteins are not shared between the Stanford and the Detroit cohorts. (B) In contrast, the highest-ranking proteins predicting GA are shared between the Stanford and the Detroit cohorts . APOB: apolipoprotein; BMP1: bone morphogenetic protein 1; BMP10: bone morphogenetic protein 10; CDK8: cyclin-dependent kinase 8:cyclin-C complex; CSF1R: macrophage colony-stimulating factor 1 receptor; DDR1: discoidin domain receptor 1; DR6: tumor necrosis factor receptor superfamily member 21; GPC3: glypican-3; GRN: granulins; GSTP1: glutathione S-transferase P; IGI-I sR: insulin-like growth factor 1 receptor; sLeptin R: Leptin receptor; MMP7: matrilysin; PIGF: placenta growth factor; PPID: peptidyl-prolyl cis-trans isomerase D; PRL: prolactin; RAN: GTP-binding nuclear protein Ran; SAP: serum amyloid P-component; SPARCL: SPARC-like protein 1; TFF3: trefoil factor 3; TXD12: thioredoxin domain-containing protein 12; XPNPEP1: Xaa-Pro aminopeptidase 1.