Retrospective analysis of leukemoid reactions in extremely preterm infants in a tertiary NICU from 2018–2021

Figures & data

Table 1. Baseline Characteristics.

Variable	Cases (n = 7)	Controls (n = 14)
Gender n (% male)	2 (28.6%)	6 (42.9%)
Maternal age (mean, SD)	32.1 (6)	32.1 (5.4)
Gestation at delivery (median, IQR)	24.571 (23.643–24.929)	24.285 (23.857–25.142)
Birthweight (mean, SD)	692.857 (98.084)	677.857 (102.673)
Apgar at 5mins <7 n(%)	5 (71.429%)	5 (35.714%)
Delivery n (% LSCS)	3 (42.85%)	9 (64.286%)
PPROM n(%)	4 (57.143%)	10 (71.429%)

Table 2. Maternal factors.

Variable	Cases (n = 7)	Controls (n = 14)	P value
Maternal CRP (median, IQR)	66.000 (26.35-104.0)	18.1(6.600–24.40)	.2151
Maternal WCC (median, IQR)	18.900(15.100–20.400)	16.450 (14.525– 19.750)	ns
Maternal Pyrexia n(%)	2 (28.571%)	1 (7.143%)	ns

Table 3. Histology with outcomes.

Cases	Maternal Risk Factors	Maternal CRP (mg/L)	Histology Maternal Side	Histology Fetal Side	Neonatal Outcome
1	GBS on HVS	<1	SI, GII	No	No BPD
2	PPROM	49	SIII, GII	SII, GII	Died day 3
3	PPROM, maternal pyrexia	19	SIII	SII	Died day 28
4	PPROM	Not available	SIII, GII	SIII, GII	NEC, BPD, ROP, PDA treated, discharged on home 02
5	PPROM	83	SIII, GII	SIII, GI	Died day 19
6	Maternal Pyrexia	111	SIII, GII	No	Died day 12
7	PPROM	114	SIII, GII	SII, GII	BPD, required HFOV and iNo, PVL

Table 4. Neonatal outcomes.

Variable	Cases (n = 7)	Controls (n = 14)
NEC n(%)	1 (14.286%)	2 (14.286%)
Death or BPD at 36/40 n(%)	6 (85.714%)	10 (71.429%)
Inotropes in first 72hrs n(%)	3(42.857%)	1 (7.143%)
Death before discharge n(%)	4 (57.143%)	5 (35.714%)
IVH n(%)	5 (83.333%)	9 (64.286%)
PVL n(%)	1 (14.286%)	0 (0%)
Hydrocortisone for hypotension in first 72hrs	2 (28.571%)	0 (0%)
Need for iNo n(%)	4 (57.143%)	4 (28.571%)
HFOV n(%)	4 (57.143%)	6 (42.857%)
RCC transfusion first 72hrs n(%)	5 (71.429%)	4 (28.571%)
No. of days ventilated (median, IQR)	18 (7.500–23.500)	6.5(2.750–24.500)
Pneumothorax n(%)	3 (42.857%)	5 (35.714%)
Doses of Surfactant 1 2 3	4 2 1	10 2 2
Need for postnatal steroids (DART) n (%)	3 (42.857%)	5 (35.714%)