Diagnostic value of platelet to lymphocyte ratio in preeclampsia: a systematic review and meta-analysis

Figures & data

Figure 1. Selection flowchart.

Table 1. The basic characteristics of the included thirteen studies in the systematic review.

Studies (year)	Country	Study design	Age (years)		NO. Of P(M&S)/C	Reference standard	Gestational week at sampling			PLR value		TP	FP	TN	FN	Cutoff
			Preeclampsia group	Control group			Preeclampsia group		Control group	Preeclampsia group	Control group
Cui 2023 [29]	China	Retro	M: 33.30 ± 4.32^a; S: 31.28 ± 4.74	30.84 ± 4.33	159(28&131)/161	ACOG	Be diagnosed as PE, or antepartum			M: 109.78 ± 39.02; S: 103.93 ± 40.10	125.25 ± 42.81	56	16	145	103	≤86.25
Melekoğlu R 2022 [28]	Turkey	Prosp	M: 32(18–44); S: 32(20–44)^b	31(20–42)^b	157(96& 61)/96	Unclear^c	Antepartum			M: 127.01(29.06–208.48); S: 106.35(38.99–388.7)^b	120.53(41.28-200)^b	39	25	71	57	136.204
G. Limonta 2021 [31]	Italy	Retro	33(26–38)^d	33(22–42)^d	25/105	ACOG	36(32–39)		40(35–41)	68(36-125)^e	107(69-166)^e	16	16	89	9	≤72.26
Long 2021 [23]	China	Retro	32.06 ± 2.51	31.58 ± 3.20	140(60& 80)/140	Obstetrics and Gynecology	35.89 ± 2.14		36.14 ± 2.36	M: 114.90 ± 41.20; S: 102.36 ± 44.70	139.93 ± 53.04	95	56	84	45	122.75
Elmaradny E 2021 [25]	Saudi Arabia	Retro	NR	NR	84/96	ACOG	Be diagnosed as PE, or antepartum			94.32 ± 30.81	138.29 ± 59.76	62	24	72	22	≤100.84
Taşkömür AT 2021 [29]	Turkey	Prosp	M: 27.96 ± 6.06; S: 26.29 ± 4.71	27.70 ± 4.74	62(48& 14)/79	ACOG	After 20 weeks			M: 145.01 ± 34.51; S: 124.85 ± 32.33	131.94 ± 37.24	31	26	53	31	118.8
Yin 2019 [26]	China	Retro	M: 27.34 ± 1.61; S: 28.54 ± 1.39	27.16 ± 1.36	80(40& 40)/30	Obstetrics and Gynecology	Second trimester			M: 113.97 ± 5.11; S: 108.12 ± 6.07	127.70 ± 5.31	40	4	26	40	＜94.38
Kholief A 2019 [31]	Egypt	Retro	NR	NR	70(35&35)/35	ACOG	After 34 weeks			M: 126.37 ± 61.16; S: 98.43 ± 59.11	125.88 ± 52.42	25	5	30	45	77.5
Kim MA 2018 [27]	Korea	Retro	M: 32.8 ± 4.6; S: 32.9 ± 4.3	33.3 ± 4.1	353(126&227)/471	ACOG	Be diagnosed as PE, or antepartum			M: 130.3 ± 4.9; S: 109.1 ± 4.5	160.8 ± 2.9	212	81	390	141	116
Mannaerts D 2017 [30]	Belgium	Retro	28.03 ± 5.06	31.96 ± 4.50^f	59/138	ACOG	Before primary cesarean section			91.47 ± 47.48	129.05 ± 40.89	41	47	91	18	109
Yu 2022 [39]	China	Retro	33.02 ± 4.41	34.11 ± 3.69	97(40&57)/388	2015 China HDCP Guidelines	First trimester			PE: 125.58 ± 47.21; M: 127.35 ± 62.38  S: 124.34 ± 33.27	128.48 ± 42.30	52	251	137	45	125.00
Oğlak SC 2021 [24]	Turkey	Retro	M: 28.3 ± 7.4; S: 28.7 ± 6.8	27.4 ± 6.1	201(94& 107)/100	ACOG	M: 7.2 ± 1.1; S: 7.4 ± 1.3	7.4 ± 1.2		M: 137.1 ± 44.9; S: 138.1 ± 38.2	121.1 ± 27.4	131	40	60	70	131.8
Gezer C 2016 [32]	Turkey	Retro	26.6 ± 6	25.8 ± 4.9	209/221	ACOG	First trimester			141.9 ± 50.8	118.5 ± 47.2	150	61	160	59	126.8

NR: No report; NO. of P(M&S)/C, number of preeclampsia patients (mild preeclampsia/severe preeclampsia)/control; Prosp: prospective; Retro: retrospective; M, mild preeclampsia; S: severe preeclampsia; HDCP: hypertensive disorders complicating pregnancy; FN: false negative; FP: false positive; TN: true negative; TP: true positive.

^a Mean ± standard deviation.

^b Median (min-max).

^c Unclear: Clinical diagnostic criteria were used, but the names of the criteria were not specified.

^d median (5th–95th percentile).

^e Mean(Mean ± SE).

^f Control group vs Preeclampsia group: p = .00.

Figure 2. Forest plots of diagnostic Performance of PLR for PE in second and third trimesters. (A) sensitivity, (B) specificity, (C) negative likelihood ratio, (D) positive likelihood ratio, (E) diagnostic odds ratio (DOR), (F) area under the summary receiver operating characteristic (SROC) curve. The first author’s name and year of each studies are listed. CI: confidence interval.

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