COVID-19 during pregnancy could potentially affect placental function

Figures & data

Table 1. Maternal demographics.

	Age (years)	Gestational age (weeks)	BMI (kg/m^2)	Severity of illness on admission	Complications	SpO2 (%)
1	27	11	22.96	1	Asthma	97
2	36	25	32.28	1		97
3	36	24	22.35	2		95
4	27	23	29.43	1	Asthma	97
5	22	18	34.99	3		93
6	23	17	27.53	1		98
7	33	16	30.67	2		95
8	23	21	26.89	1		98

BMI: body mass index.

Figure 1. (A, B) Normal pregnancies and (C, D) pregnancies with a history of COVID-19 disease. (A, C) Diagrams of placental area designation. (B, D) Changes in ΔR2* values with maternal oxygen administration. Maternal oxygen is administered between 240 and 480 s, indicating increased ΔR2* values.

Table 2. Fetal, neonatal, and placental demographics.

	GA on MRA (weeks)	EFW (SD)	UA-PI	UA-PI (%ile)	Delivery (weeks)	Birth weight (g)	Birth weight (%ile)	Sex	Apgar (1 min)	Apgar (5 min)	pH	BE	Placental weight (g)
1	35	−0.1	0.97	66	39	2664	25.4	F	9	9	NA	NA	542
2	34	0.3	1.12	88	40	3590	84.6	F	9	10	7.25	−4.2	626
3	35	0.6	0.63	2	40	3450	70.0	M	9	10	7.24	−8	623
4	34	−0.9	0.67	3	38	2776	33.8	M	10	10	7.33	−5.5	470
5	34	1.4	1	67	39	2982	47.7	M	8	9	7.24	−7.9	518
6	33	1	0.81	19	37	3000	82.3	M	8	9	7.17	−10	452
7	33	0.9	1.11	84	39	3692	96.6	F	10	10	7.40	−2	561
8	35	−1.5	0.51	1	40	2320	0.8	F	4	9	7.24	−3.7	752

BE: base excess; GA: gestational age; MRI: magnetic resonance imaging; NA: not applicable; UA-PI: umbilical artery pulsatility index.

Table 3. Comparison between the normal pregnancy group and the COVID-19 group.

	COVID-19	Normal	p Value
Number	8	18
Maternal variables
Age (years)	27 (23, 34)	32 (29, 40)	.0470
Gravidity	1.0 (1, 2)	1.5 (1, 2)	.531
MRI (days)	239 (238, 246)	245 (238, 248)	.429
Neonatal variables
Delivery (days)	276 (273, 283)	270 (264, 279)	.160
Birth weight (g)	2991 (2748, 3485)	2850 (2717, 3035)	.461
Birth weight (%ile)	58.8 (31.7, 82.8)	45.2 (27.3, 64.2)	.461
Sex (male:female)	4:4	7:11
Placental variable
Placental weight (g)	551.5 (506.0, 623.75)	531.0 (465.5, 573.8)	.397

MRI: magnetic resonance imaging.

Values are presented as median (interquartile range).

Table 4. Results of BOLD-MRI.

	Normal	COVID-19	p Value
ΔR2*	8 ± 3	5 ± 1	<.001
Time to ΔR2* (s)	458 ± 74	471 ± 33	.644

BOLD-MRI: blood oxygen level-dependent magnetic resonance imaging.

Data availability statement

The data that support the findings of this study are available on request because the data contain potentially identifying or sensitive patient information. This restriction is imposed by the Institutional Review Board (Contact; Data Manager: [email protected]).