Is CT-derived fractional flow reserve superior to ischemia testing?

Figures & data

Table 1. Diagnostic performance of CTA, FFR_CT, and different noninvasive ischemia testing modalities in patients with stable CAD and intermediate range coronary artery stenosis determined by CTA. All prospective studies measured FFR as the reference standard

Study [Ref.]	Testing modality	Per-patient			Per-vessel
		Sens, %	Spec, %	Acc, %	Sens, %	Spec, %	Acc, %
NXT [7]	FFRCT	86	79	81	84	86	86
	CTA	94	34	53	83	60	65
DANICAD [12]	SPECT	36	93	70	33	92	80
	CMR	41	84	67	28	88	75
PACIFIC [9]	FFRCT	96	63	78	90	86	87
	CTA	87	67	76	68	83	79
PACIFIC [8]	SPECT	57	94	77	39	96	82
	PET	87	84	85	81	75	79
ReASSESS [10]	FFRCT	91	55	70	-	-	-
	SPECT	41	86	68	-	-	-

NXT [7], 254 patients, 484 vessels; DANICAD [12], 148 patients, 452 vessels; PACIFIC [9], 157 patients, 505 vessels; PACIFIC [8], 208 patients, 554 vessels; and ReASSESS [10], 143 patients, no per-vessel analyses.

CMR, cardiac magnetic resonance; CTA, coronary CT angiography; FFR_CT, CTA-derived FFR; SPECT, Single photon emission CT; PET, Positron emission tomography.

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