The colleflaccinosides, two chiral bianthraquinone glycosides with antitumor activity from the lichen Collema flaccidum collected in Israel and Russia

Abstract

Colleflaccinosides A and B, two chiral bianthraquinone glycosides from the two geographical varieties of lichen Collema flaccidum collected in Russia and Israel have been isolated as new natural products. Their structures were elucidated using UV, CD, IR, MS, 1D and 2D NMR spectral data, and chemical degradation. The colleflaccinosides B had significant antitumor activity in the crown gall tumor inhibition test.

Keywords:

• Collema flaccidum
• Jelly lichen
• Israel
• Russia
• Bianthraquinone glycosides
• Colleflaccinosides A and B
• Antitumor activity
• Facility Mayak