Abstract
Three new diterpene glycosides, virescenosides V (1), W (2), and X (3) have been isolated from a marine strain of Acremonium striatisporum KMM 4401 associated with the holothurian Eupentacta fraudatrix. Their structures have been elucidated on the basis of high resolution mass spectrometry, 1D and 2D NMR (1H, 13C, DEPT, COSY 45, COSY RCT, HSQC, HMBC, and NOESY spectra) as 19-O-β-D-altropyranosyl-7-oxo-isopimara-8(14),15-diene-2α,3β-diol (1), 19-O-β-D-altropyranosyl-isopimara-7,15-diene-2α,3β,6α-triol (2), and 19-O-β-D-altropyranosyl-isopimara-8,15-diene-2α,3β,7α-triol (3).
Acknowledgment
This work was supported financially by grants of the Russian Foundation for Basic Research (projects No. 03-04-49528, 05-04-48291), a grant of the RF President No. 1237.2003.4, grant No. 2-2.16 of the Federal Agency for Science and Innovation of the Ministry of Education and Science of the RF, and grant No. 04-1-05-005 of the RAS Presidium “Molecular and Cellular Biology”.