Abstract
The fungus, Absidia coerulea was employed to bioconvert tetrahydro-α-santonins, 1,2,4α,5α-tetrahydro-α-santonin (1), and its 4-epimer (2), from which 10 products (3–12) were obtained. Furthermore, their structures were determined, based on their chemical and spectroscopic data analyses. Among them, 3–5, 7, 9, 11 and 12 were observed to be seven new compounds. The reactions mainly involved in these bio-process included hydroxylation(s) (C-4, C-11, and C-1), reduction (C-3 ketone to alcohol).
Acknowledgements
This work was supported by the “211” and “985” Projects of The Central University for Nationalities.