Abstract
Three novel metabolites (1, 5 and 10) were isolated from a 25-L fermentation broth of Actinomyces sp. JN411010 together with 11 related compounds. Their structures were determined on the basis of 1D and 2D NMR, as well as HR-ESI-MS spectroscopic data analyses. Compounds 1–2, 5–8 and 10 displayed moderate antimicrobial activities against Gram-positive and Gram-negative bacteria. Biosynthetic pathway of 5 and 10 was proposed to be catalysed by polyketide and non-ribosomal peptide gene clusters, respectively.
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Acknowledgements
This work was partially supported by Chinese Sika deer standardised system and product development of key technical project (2011DFA32900, Ministry of Science and Technology of the People's Republic of China) and funded by Jilin China–Korea Joint Institute for Animal Science. We are grateful to Dr Jingwei Xu from National Analytical Research Center of Electrochemistry and Spectroscopy for supplying the NMR spectra.