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Natural Product Research
Formerly Natural Product Letters
Volume 28, 2014 - Issue 1
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Articles

New briarane-type diterpenoids from gorgonian Ellisella dollfusi from the South China Sea

Yuan-Ming ZhouKey Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, P.R. China;College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266109, P.R. China
,
Chang-Lun ShaoKey Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, P.R. China
,
Hui HuangSouth China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510000, P.R. China
,
Xiu-Li ZhangKey Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, P.R. China
&
Chang-Yun WangKey Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, P.R. ChinaCorrespondence[email protected]
Pages 7-11 | Received 25 Mar 2013, Accepted 11 Jun 2013, Published online: 25 Aug 2013
 
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Abstract

Two new briarane-type diterpenoids, dollfusilin A (1) and dollfusilin B (2), along with five known briarane-type diterpenoids (3–7), were isolated from the gorgonian Ellisella dollfusi collected from the South China Sea. The structures of the two new compounds (1 and 2) were elucidated through a comprehensive analysis of spectroscopic data, especially 2D NMR. The bioactivities of the isolated compounds were evaluated using the zebrafish toxicity model.

Acknowledgements

This work was supported by the Key Program of the National Natural Science Foundation of China (No. 41130858), the National Natural Science Foundation of China (Nos 41176121 and 81172977), the National High Technology Research and Development Program of China (863 Program) (No. 2013AA093001) and the Natural Science Foundation of Shandong Province (Nos ZR2011DQ019 and ZR2011HM085).

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