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Natural Product Research
Formerly Natural Product Letters
Volume 29, 2015 - Issue 18
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Articles

A new lignan with hypoglycemic activity from Tadehagi triquetrum

Jiani WuSchool of Pharmaceutical Science, Hainan Medical University, Haikou571101, P.R. China;Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin150076, P.R. China
,
Cai yun ZhangSchool of Pharmaceutical Science, Hainan Medical University, Haikou571101, P.R. China
,
Tingting ZhangSchool of Pharmaceutical Science, Hainan Medical University, Haikou571101, P.R. China;Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin150076, P.R. China
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Dan ZhaoSchool of Pharmaceutical Science, Hainan Medical University, Haikou571101, P.R. China;Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin150076, P.R. China
,
Ni AnSchool of Pharmaceutical Science, Hainan Medical University, Haikou571101, P.R. China;Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin150076, P.R. China
,
Youbin LiSchool of Pharmaceutical Science, Hainan Medical University, Haikou571101, P.R. China
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Nailiang ZhuInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100193, P.R. China
,
Shuai WangResearch Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin150076, P.R. China
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Feng ChenSchool of Pharmaceutical Science, Hainan Medical University, Haikou571101, P.R. ChinaCorrespondence[email protected] [email protected]
&
Xiaopo ZhangSchool of Pharmaceutical Science, Hainan Medical University, Haikou571101, P.R. China
 show all
Pages 1723-1727 | Received 18 Oct 2014, Accepted 24 Dec 2014, Published online: 22 Jan 2015
 
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Abstract

A new lignan named tadehaginosin, together with a known compound 3,4-dihydro-4-(4′-hydroxyphenyl)-5,7-dihydroxycoumarin, was isolated from the aerial part of Tadehagi triquetrum. The new structure was determined by various spectroscopic techniques (1H and 13C APT, HSQC, HMBC, 1H–1HCOSY, NOESY and HR-ESI-MS). The two isolates were evaluated for their hypoglycemic effects in vitro. Biological investigation showed that both of them possessed the capability to increase glucose consumption by HepG2 cells.

Funding

The financial assistance given by the Natural Sciences Foundation of China [grant number 81202994] is gratefully acknowledged.

Notes

1. These authors contributed equally to this work.

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