A new bibenzyl derivative with nuclear factor-kappaB inhibitory activity from Schefflera arboricola (Araliaceae)

Abstract

A new bibenzyl derivative (1), 4-acetoxy-3,5,3′,4′-tetramethoxybibenzyl, along with eight known compounds (2–9), was isolated from the twigs and leaves of Schefflera arboricola (Araliaceae). The isolated compounds were elucidated mainly by means of one-dimensional, two-dimensional NMR and MS, and by comparison with the literature data. Compounds 2–5 and 7–9 are first reported from this plant. In the in vitro assays, compound 1 displayed moderate nuclear factor-kappaB inhibitory activity.

Keywords::

• Schefflera arboricola
• bibenzyl derivative
• nuclear factor-kappaB inhibitory activity

Additional information

Funding

This work was supported by grants from the National Natural Science Foundation of China [grant number 81102782]; the Postdoctoral Science Foundation of China [grant number 2011M501368]; and the Priming Scientific Research Foundation for the Junior Teacher of Medicine in Sun Yat-sen University.