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Abstract
A new diketopiperazine (DKP) derivative, (6R,3Z)-3-benzylidene-6-isobutyl-1-methyl piperazine-2,5-dione (1), as well as five known DKPs 2–6 was isolated from a deep sea-derived Streptomyces sp. SCSIO 04496. The structure of 1 was elucidated using a combination of 1D and 2D NMR, HR-ESI-MS and chiral-phase HPLC techniques. Compounds 1–6 did not show cytotoxic activity at a concentration of 100 μM in bioactivity assay.
Acknowledgement
We are grateful to Mr Li, Mrs Sun, Mrs Xiao and Miss Zhang of the South China Sea Institute of Oceanology for recording NMR and MS data.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This study was supported in part by MOST [grant number 2012AA092104], the National Natural Science Foundation of China for Young Scientists [grant number 41106138], international S&T cooperation program of China [grant number 2011DFA32540] and the Knowledge Innovation Programs of CAS [grant numbers KZCX2-YW-JC202; KSCX2-EW-G-12].