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Abstract
A novel phenylethanoid glycoside, 3′-O-methyl isocrenatoside (1), along with two known compounds, methyl caffeate (2) and protocatechuic aldehyde (3), were isolated from the fresh whole plant of Orobanche cernua Loefling. All the isolated compounds (1–3) were elucidated on the basis of spectroscopic analysis including IR, MS and NMR data. The cytotoxic activities of these compounds were evaluated. Results showed that 3′-O-methyl isocrenatoside (1) and methyl caffeate (2) exhibited significant cytotoxicity, with IC50 values of 71.89, 36.97 μg/mL and 32.32, 34.58 μg/mL against the B16F10 murine melanoma and Lewis lung carcinoma cell lines, respectively.
Graphical abstract
Acknowledgement
We thank Gao-Fei Hu (College of Science, Beijing University of Chemical Technology) for measuring the NMR spectra.
Disclosure statement
No potential conflict of interest was reported by the authors.
Funding
This work was financially supported by National Key Technology Research and Development Program of the Ministry of Science and Technology of China [grant number 2011BAI03B01].