A novel 10-hydroxycamptothecin-glucoside from the fruit of Camptotheca acuminata

Abstract

Glycosides were isolated from the fruit of Camptotheca acuminata and identified using NMR, MS, UV and IR spectrometries. 10-O-(1-β-D-glycosyl) camptothecin (1) was identified for the first time in a natural material. In addition, compounds 2–4 were firstly reported from the fruits of C. acuminata and indentified as syringaresinol-4, 4′-O-bis-β-D-glucoside (2), hyperoside (3) and pumiloside (4), respectively. Two known compounds, vincoside-lactam (5) and strictosidinic acid (6), were also obtained.

Keywords:

• Camptotheca acuminata
• glycoside
• 10-O-(1-β-D-glycosyl) camptothecin
• syringaresinol-4, 4′-O-bis-β-D-glucoside

Disclosure statement

No potential conflict of interest was reported by the authors.