A new biflavonoid from the whole herb of Lepisorus ussuriensis

Abstract

A new biflavonoid, 7-O-methylnaringenin-(4′→O→6″)-scutellarein (1), together with 11 known compounds (2–12) were isolated from the whole herb of Lepisorus ussuriensis. The structure of compound 1 was elucidated by spectroscopic analyses. Amongst them, dihydroquercetin (6), diosmetin (9), baicalein (11) and 7,8-dihydroxyflavone (12) were reported from the family Polypodiaceae for the first time. Meanwhile, quercetin (7), diosmetin (9) and luteolin (10) inhibited TNF-α-induced NF-κB reporter gene expression on HeLa cells up to 30 and 100 μM.

Graphical abstract

Keywords:

• Polypodiaceae
• Lepisorus ussuriensis
• biflavonoid
• anti-inflammatory activity
• nuclear factor-κB (NF-κB)

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

This work was supported by the National Natural Science Foundation of China [grant number 81160386], [grant number 81260474]. This work was also partially supported by Jilin Provincial Science & Technology Department.