Pyrrolizidine alkaloids from Solenanthus lanatus DC. with acetylcholinesterase inhibitory activity

Abstract

The whole plant ethanolic extract of Solenanthus lanatus was used for the isolation of acetylcholinesterase inhibitors. A new pyrrolizidine alkaloid, 7-O-angeloylechinatine N-oxide, 1, was isolated together with three known compounds of the same class (3′-O-acetylheliosupine N-oxide, 2, heliosupine N-oxide, 3, and heliosupine, 4), by bioassay-guided approach. Their structures were elucidated by spectroscopic methods. All the isolated compounds showed inhibition activity against the AChE, with IC₅₀ 0.53–0.60 mM.

Keywords:

• Boraginaceae
• Solenantus lanatus
• pyrrolizidine alkaloids
• 7-O-angeloylechinatine N-oxide
• anti-AChE activity

Acknowledgement

The authors wish to thank Mr A. Ahedmessaoud and Mr K. Ballot for botanical investigation and plant collection.

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

The authors wish to thank the Ministry of Higher Education and Scientific Research of Algeria for financial support [grant number F02220120052].