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Natural Product Research
Formerly Natural Product Letters
Volume 31, 2017 - Issue 3
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Research Article

Cycloartane-type triterpenoids from Astragalus hoantchy French.

Kai GuoKey Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, P.R. China
,
Xiaofeng HeKey Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, P.R. China
,
Dengxue LuInstitute of Biology, Gansu Academy of Sciences, Lanzhou, P.R. China
,
Yanping ZhangFisheries Research Institute of Gansu Province, Lanzhou, P.R. China
,
Xiuzhuang LiKey Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, P.R. China
,
Zhiqiang YanKey Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, P.R. China
&
Bo QinKey Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, P.R. ChinaCorrespondence[email protected]
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Pages 314-319 | Received 17 Jun 2016, Accepted 27 Aug 2016, Published online: 22 Sep 2016
 
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Abstract

A new cycloartane-type triterpenoid, 3β-acetoxy-9β,19-cyclolanost-24E-ene-1α,16β-diol-27-O-β-d-glucopyranoside (1), together with three known ones (2–4) were isolated from the aerial parts of Astragalus hoantchy. The structure of compound 1 was elucidated by detailed spectroscopic analyses including 1D and 2D NMR, HRESIMS, and IR experiments. All of the four compounds were isolated from A. hoantchy for the first time. The antifungal activities of compounds 1–4 against a phytopathogenic fungus (Alternaria solani) were evaluated with the result that compound 3 exhibited a moderate activity with an IC50 value of 284 μg/mL.

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