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Natural Product Research
Formerly Natural Product Letters
Volume 31, 2017 - Issue 7
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Research Articles

Two new benzoate derivatives and one new phenylacetate derivative from a marine-derived fungus Engyodontium album

Weiyi WangKey Laboratory of Marine Biogenetic Resources, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Third Institute of Oceanography, State Oceanic Administration, Xiamen, China;Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, China
,
Ruixuan ChenKey Laboratory of Marine Biogenetic Resources, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Third Institute of Oceanography, State Oceanic Administration, Xiamen, China
,
Zhuhua LuoKey Laboratory of Marine Biogenetic Resources, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Third Institute of Oceanography, State Oceanic Administration, Xiamen, China
,
Wei WangKey Laboratory of Marine Biogenetic Resources, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Third Institute of Oceanography, State Oceanic Administration, Xiamen, China
&
Jianming ChenKey Laboratory of Marine Biogenetic Resources, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Third Institute of Oceanography, State Oceanic Administration, Xiamen, ChinaCorrespondence[email protected]
Pages 758-764 | Received 30 Jun 2016, Accepted 09 Sep 2016, Published online: 18 Oct 2016
 
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Abstract

Two new benzoate derivatives, ethyl 3,5-dimethoxy-2-propionylbenzoate (1) and ethyl 3,5-dihydroxy-2-propionylbenzoate (2), and one new phenylacetate derivative, ethyl 3,5-dimethoxy-2-propionylphenylacetate (3), together with 9 known compounds, were isolated from the fermentation of Engyodontium album derived from deep sea sediment. Their structures were elucidated by spectroscopic techniques, such as NMR, IR and HRESIMS. Compound 3 exhibited inhibitory activities against methicillin-resistant Staphylococcus aureus ATCC 43300 (MRSA) and Vibrio vulnificus, with MIC values of 7.8 and 15.6 μg/mL, respectively.

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