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Natural Product Research
Formerly Natural Product Letters
Volume 32, 2018 - Issue 16
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Short Communication

Chemical analysis and antiviral activity evaluation of Baccharis anomala

Caroline Rita VenturiFaculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil
,
Srgio Augusto De Loreto BordignonPrograma de Pós-graduação em Avaliação de Impactos Ambientais, Centro Universitário La Salle, Canoas, Brazil
,
Paulo Michel RoeheInstituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, BrazilCorrespondence[email protected]
,
Jarbas Alves MontanhaFaculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, BrazilCorrespondence[email protected]
,
Samuel Paulo CibulskiInstituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil
&
Grace GosmannFaculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil
Pages 1960-1962 | Received 04 Apr 2017, Accepted 20 Jun 2017, Published online: 19 Jul 2017
 
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Abstract

The chemical composition and antiviral activity of aqueous extract from Baccharis anomala was studied by bioactivity-guided fractionation. Ethanol precipitation and fractionation by molecular permeation allowed the separation of the anti-herpes simplex virus 1 (HSV-1) active fraction from aqueous extract (Fraction B). Natural Product Reagent A, FeCl3 and thin-layer chromatography indicated the presence of phenolic compounds in the aqueous extract. Fraction B showed pronounced antiviral activity when tested with HSV-1 strains VR733/ATCC and Acyclovir-resistant 29-R, displaying virucidal but not virustatic activity.

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