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Natural Product Research
Formerly Natural Product Letters
Volume 32, 2018 - Issue 8
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Research Article

Colletotrichine A, a new sesquiterpenoid from Colletotrichum gloeosporioides GT-7, a fungal endophyte of Uncaria rhynchophylla

Xiao-Wei ChenSchool of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, P.R. China
,
Zhong-Duo YangSchool of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, P.R. China;The Provincial Education Key Laboratory of Screening, Evaluation and Advanced Processing of Traditional Chinese Medicine and Tibetan Medicine, School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, P.R. ChinaCorrespondence[email protected]
,
Jian-hui SunSchool of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, P.R. China
,
Tong-tong SongSchool of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, P.R. China
,
Bao-ying ZhuSchool of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, P.R. China
&
Jun-wen ZhaoSchool of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, P.R. China
Pages 880-884 | Received 04 May 2017, Accepted 30 Jul 2017, Published online: 14 Aug 2017
 
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Abstract

One new compound, Colletotrichine A (1), was produced by the fungal Colletotrichum gloeosporioides GT-7. The structure was established by 1D and 2D NMR spectra. Monoamine oxidase (MAO) and acetylcholinesterase (AChE) inhibitory activity of 1 was also evaluated. Compound 1 showed AChE-inhibiting activity with IC50 value of 28 μg/mL.

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