Two new lignans from the resin of Bursera microphylla A. gray and their cytotoxic activity

Abstract

Two new lignans, namely 7-O-podophyllotoxinyl butyrate (1) and dihydroclusin 9-acetate (2), were isolated from the dichloromethane fraction of a methanol extract of Bursera microphylla (Burseraceae), along with eight known lignans (3–10). Their structures were determined by means of comprehensive spectroscopic analysis. Lignans 2–6 were tested for their anti-proliferative activity on the cancer cell lines LS180, A549 and HeLa, and on a non-cancer cell line, ARPE-19. Only compounds 4 and 5 showed an interesting activity on HeLa cells.

Keywords:

• Bursera microphylla
• Burseraceae
• lignans
• dihydroclusin 9-acetate
• 7-O-podophyllotoxinyl butyrate
• anti-proliferative activity

Acknowledgement

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