Antiangiogenic phenylpropanoid glycosides from Gynura cusimbua

Abstract

A new phenylpropanoid glycoside, named α-L-rhamnopyranosyl-(1↔2)-β-D-[4″-(8E)-7-(3,4-dihydroxyphenyl)-8-propenoate, 1″-O-(7S)-7-(3,4-dihydroxyphenyl)-7-methoxy-ethyl]-glucopyranoside (1), together with nine known compounds (2–10) were isolated from the active fraction (n-Butanol fraction) of Gynura cusimbua for the first time. The known compounds (2–10) were identified as phenylpropanoid glycosides on the basis of extensive spectral data and references. The antiangiogenic activities of compounds (1–10) were evaluated by MTT assay on HUVECs and wild-type zebrafish in vivo model assay. As a result, compounds 1, 6, 7, 8 and 10 exhibited certain antiangiogenic activities.

Keywords:

• Gynura cusimbua
• phenylpropanoid glycosides
• antiangiogenic activities

Acknowledgements

We are grateful to the Department of Instrumental Analysis of Jiangxi Science & Technology Normal University and Nanyang Normal University for measurements of UV, IR, NMR and MS.