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Natural Product Research
Formerly Natural Product Letters
Volume 32, 2018 - Issue 15
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Research Article

A new bischromanone from the stems of Semecarpus caudata

Phu H. DangFaculty of Chemistry, VNUHCM–University of Science, Ho Chi Minh City, Vietnam
,
Tinh T. NguyenFaculty of Chemistry, VNUHCM–University of Science, Ho Chi Minh City, Vietnam
,
Tho H. LeFaculty of Chemistry, VNUHCM–University of Science, Ho Chi Minh City, Vietnam
,
Hai X. NguyenFaculty of Chemistry, VNUHCM–University of Science, Ho Chi Minh City, Vietnam
,
Mai T. T. NguyenFaculty of Chemistry, VNUHCM–University of Science, Ho Chi Minh City, Vietnam;Cancer Research Laboratory, Vietnam National University, Ho Chi Minh City, Vietnam
&
Nhan T. NguyenFaculty of Chemistry, VNUHCM–University of Science, Ho Chi Minh City, Vietnam;Cancer Research Laboratory, Vietnam National University, Ho Chi Minh City, VietnamCorrespondence[email protected]
Pages 1745-1750 | Received 17 Sep 2017, Accepted 21 Oct 2017, Published online: 08 Nov 2017
 
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Abstract

From an CHCl3-soluble fraction of the stems of Semecarpus caudata, one new bischromanone named semecarpanone (1), together with 5 known flavonoids (2–6) were isolated. Their structures were elucidated based on interpretation of spectroscopic data. The stereo-configuration of 1 was identified based on the calculated and experimental coupling constants. Compounds 4–6 showed potent tyrosinase inhibitory activity with the IC50 values ranging from 15.0 to 76.3 μM.

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