Two new clerodane-type diterpenoids from Bornean liverwort Gottschelia schizopleura and their cytotoxic activity

Abstract

The Bornean liverwort Gottschelia schizopleura was investigated phytochemically for the first time. Two new and four previously known clerodane-type diterpenoids were isolated from the MeOH extract of G. schizopleura through a series of chromatographic techniques. The structures of the new metabolites were established by analyses of their spectroscopic data (1D NMR, 2D NMR, HRESIMS and IR). All the isolated compounds 1–6 were tested against human promyelocytic leukaemia (HL-60), human colon adenocarcinoma (HT-29) and Mus musculus skin melanoma (B16-F10). Compound 1 and 2 showed active inhibition against HL-60 and B16-F10 cells.

Keywords:

• Clerodane diterpenoids
• Gottschelia schizopleura
• Jungermanniaceae
• liverwort
• Borneo
• cytotoxic activity

Acknowledgement

The authors are grateful to the Sabah Parks for the support and assistance during field survey. We would like to acknowledge Prof. Dr Tatsufumi Okino, Hokkaido University and Mr Takafumi Ishikawa, Hokkaido University, for their kind assistance during data comparison.