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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 16
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Research Articles

Potential hypoglycemic effect of acetophenones from the root bark of Cynanchum wilfordii

Hao-Wen JiangShanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai, People’s Republic of China;State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
,
Shan-Shan GuSchool of Pharmacy, Nantong University, Nantong, People’s Republic of China;Department of Pharmacy, Nantong Hospital of Traditional Chinese Medicine, Nantong, People’s Republic of China
,
Lei CaoSchool of Pharmacy, Nantong University, Nantong, People’s Republic of China
,
Sheng-Shi JiangDepartment of Pharmacy, Nantong Hospital of Traditional Chinese Medicine, Nantong, People’s Republic of China
,
Jing LinSchool of Pharmacy, Nantong University, Nantong, People’s Republic of China
,
Yan ChenSchool of Pharmacy, Nantong University, Nantong, People’s Republic of China
,
Ling WangSchool of Pharmacy, Nantong University, Nantong, People’s Republic of China
,
He JiaoSchool of Pharmacy, Nantong University, Nantong, People’s Republic of China
,
Jing-Ya LiState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of ChinaCorrespondence[email protected]
,
Wei-Min ZhaoState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of ChinaCorrespondence[email protected]
&
Jin-Long LiSchool of Pharmacy, Nantong University, Nantong, People’s Republic of China;State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-0915-4095
ORCID Icon show all
Pages 2314-2321 | Received 01 Jan 2018, Accepted 15 Feb 2018, Published online: 25 Feb 2018
 
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Abstract

Three new acetophenones, named cynwilforones A–C (1–3), together with cynandione A (4) were isolated from the root bark of Cynanchum wilfordii (Maxim.) Hemsl. Their structures were deduced based on spectroscopic analysis and chemical methods. Compounds 1 and 4 exhibited potential hypoglycemic effects through inhibition of hepatic gluconeogenesis by down-regulating the expression of phosphoenolpyruvate carboxykinase and glucose-6-phosphatase. This is the first report that acetophenones from the root bark of C. wilfordii possesses potential hypoglycemic activity in vitro.

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