New cembrane-type diterpenoids from Bornean soft coral Nephthea sp. with antifungal activity against Lagenidium thermophilum

Abstract

Three new cembrane diterpenes, nephthecrassocolides A-B (1–2) and 6-acetoxy nephthenol acetate (3) along with three known compounds, 6-acetoxy-7,8-epoxy nephthenol acetate (4), epoxy nephthenol acetate (5) and nephthenol (6) were isolated from one population of Nephthea sp. Their structures were elucidated based on spectroscopic data analysis and the antifungal activities of compounds 1–6 were evaluated.

Keywords:

• Nephthea sp.
• soft coral
• cembrane
• diterpene
• antifungal

Acknowledgement

The authors would like to acknowledge Prof. Dr Tatsufumi Okino from Hokkaido University for SciFinder Database and Prof. Dr Kishio Hatai from Universiti Malaysia Sabah for providing fungal strains.