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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 13
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Research Articles

Asperpyrone F, a new dimeric naphtho-γ-pyrone from the edible fungus Pleurotus ostreatus

Xu CaiKey Laboratory of Ministry of Education for Traditional Chinese Medicine Resource and Compound Prescription, Hubei University of Chinese Medicine, Wuhan, P.R. China;Key Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing, P.R. China
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Yang YuCollege of Pharmacy, Shandong University Of Traditional Chinese Medicine, Jinan, P.R. China
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Qian LiKey Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing, P.R. China
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Ben-Ke ChenKey Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing, P.R. China
,
Yun HuangKey Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing, P.R. China
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Xian-Wei ZouKey Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing, P.R. ChinaCorrespondence[email protected]
,
Jin-Tian TangKey Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing, P.R. ChinaCorrespondence[email protected]
&
Bi-Sheng HuangKey Laboratory of Ministry of Education for Traditional Chinese Medicine Resource and Compound Prescription, Hubei University of Chinese Medicine, Wuhan, P.R. ChinaCorrespondence[email protected]
 show all
Pages 1953-1960 | Received 29 Mar 2018, Accepted 21 May 2018, Published online: 01 Jun 2018
 
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Abstract

A new dimeric naphtho-γ-pyrone, asperpyrone F (1), along with six known ones, asperpyrones B (2) and C (3), fonsecinones A (4) and B (5), aurasperones A (6) and E (7), have been isolated from the solid culture of the edible fungus Pleurotus ostreatus. The structures of 1–7 were determined mainly by NMR and MS experiments. The absolute configuration of compound 1 was assigned via the circular dichroism (CD) data analysis. Compounds 1–7 showed modest antioxidant and immunomodulatory activities. All compounds were isolated from the fungus P. ostreatus for the first time.

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