Chemical constituents and cytotoxic activity from the wood-decaying fungus Xylaria sp. SWUF08-37

Abstract

A new cyclic pentapeptide, pentaminolarin (1), and a new cytochalasin, xylochalasin (2), along with thirteen known compounds (3–15) were isolated from the wood-decaying fungus Xylaria sp. SWUF08-37. The absolute configurations of 1 were determined by a combination of Marfey’s method and TDDFT ECD calculation and the absolute configurations of 2 were established by TDDFT ECD calculation. Compound 12 showed moderate cytotoxicity against HeLa (IC₅₀ = 19.60 µg/mL), HT29 (IC₅₀ = 17.31 µg/mL), HCT116 (IC₅₀ = 14.28 µg/mL), MCF-7 (IC₅₀ = 15.38 µg/mL), and Vero (IC₅₀ = 24.97 µg/mL) cell lines by MTT assay. Compounds 1 and 2 showed slight cytotoxicity against all tested cancer cell lines.

Graphical Abstract

Keywords:

• Xylariaceae
• wood decaying fungus
• cyclic pentapeptide
• cytochalasin
• cytotoxic activity

Acknowledgements

This work was supported by the Development and Promotion of the Gifted in Science and Technology Project (DPST) and the Centre of Excellence for Innovation in Chemistry (PERCH-CIC), Office of the Higher Education Commission and the Ministry of Education (OHEC).

Disclosure statement

No potential conflict of interest was reported by the authors