New bisbibenzyl and phenanthrene derivatives from Dendrobium scabrilingue and their α-glucosidase inhibitory activity

Abstract

Phytochemical investigation of the whole plant of Dendrobium scabrilingue resulted in the isolation of two new compounds namely dendroscabrols A (1) and B (2), along with eight known compounds (3–10). The structures of these compounds were determined by NMR and HR-ESI-MS experiments. All of the isolates were evaluated for their α-glucosidase inhibitory effect. Dendroscabrol B (2) and RF-3192C (10) showed the most potent α-glucosidase inhibitory activity. Dendroscabrol A (1), gigantol (5), coelonin (7) and lusianthridin (9) also exhibited strong activity as compared with the positive control acarbose.

Graphical abstract

Keywords:

• Dendrobium scabrilingue
• Orchidaceae
• bisbibenzyl
• phenanthrene
• α-glucosidase

Disclosure statement

The authors declare no conflicts of interest.

Funding

C.S. is grateful to Chulalongkorn University Graduate Scholarship to commemorate the 72nd Anniversary of his Majesty King Bhumibala Aduladeja.

Figure 1. Structures of compounds from Dendrobium scabrilingue.