Prenylated isoflavones with potential antiproliferative activities from Mappianthus iodoides

Abstract

A phytochemical investigation on the stems of Mappianthus iodoides led to the isolation of a new naturally occurring prenylated isoflavone, mappianthone A (1), together with seven known analogues (2−8). The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparison with data reported in the literature. All isolated compounds were evaluated for their antiproliferative activities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 1−8 showed significant antiproliferative effects against several human cancer cell lines with IC₅₀ values ranging from 0.16 to 12.68 μM.

Keywords:

• antiproliferative activities
• Mappianthus iodoides
• mappianthone A
• prenylated isoflavone

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China (Nos. 21662011 and 31660097), the Key Research and Development Project of Haikou (No. 2017050), the Program for Innovative Research Team in University (No. IRT-16R19), the Special Project of the Central Government for the Development of Local Science and Technology (No. ZY2018HN07) and the Fund of Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization (No. FPRU201507).