A new highly oxygenated abietane diterpenoid and a new lysosome generating phorbol ester from the roots of Euphorbia fischeriana Steud

Abstract

Twenty-two diterpenoids (1–22), including two new ones (1, a tigliane-type diterpenoid and 8, an abietane-type diterpenoid) were isolated from the roots of Euphorbia fischeriana Steud. Among them, compounds 4, 7, 12, 14–16, 19–21 are isolated from this plant for the first time. Their structures were elucidated through extensive 1D, 2D NMR and the HRESIMS data. The ¹³C data of 4 is hereby presented for the first time. The macrocyclic diterpenes 1 and 2 showed marked enhancement of lysosomal biosynthesis after evaluation using lysoTracker staining method.

Graphical Abstract

Keywords:

• Euphorbia fischeriana Steud
• highly oxygenated abietanes
• phorbol esters
• lysosomal biogenesis

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research was supported financially by grants from the National Science Foundation of China (21432010), Technological leading talent project of Yunnan (2015HA020), the Youth Innovation Promotion Association of CAS (2015323), and the Young Academic and Technical Leader Raising Foundation of Yunnan Province (to Y.Z.).