FW0622, a new siderophore isolated from marine Verrucosispora sp. by genomic mining

Abstract

Using the draft genome sequence of Verrucosispora sp. FIM060022, we have identified a new desferrioxamine-like siderophore, FW0622. This is the first chemically characterized siderophore obtained from Verrucosispora. The structure was elucidated by extensive spectral analyses. The biosynthetic pathway of FW0622 was proposed to occur via the non-ribosomal peptide synthetase (NRPS)-independent (NIS) synthetase pathway based on the putative biosynthetic siderophore gene cluster in FIM060022. The results demonstrate that marine-derived Verrucosispora species deserve recognition as an important source of new natural products. Furthermore, this study verified that genome mining is an effective way to identify compounds that may be overlooked by traditional methods.

Graphical Abstract

Keywords:

• Genome mining
• siderophore
• biosynthesis pathway
• Verrucosispora

Acknowledgements

This work was supported by the National Key R&D Program of China under grant number 2018YFC0311001; The Drug Innovation Major Project under grant number 2018ZX09711001-007-007. Sequencing services were provided by Personal Biotechnology Co., Ltd., Shanghai, China.

Disclosure statement

The authors declare no conflict of interest.