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Abstract
A new demethyl abietane diterpenoid, Triptotin K (3) together with three known compounds, friedelin (1), canophyllal (2), and triptonoterpene (4) were isolated from the roots of Tripterygium wilfordii Hook. f. by silica gel column and preparative high performance liquid chromatography. Their structures were determined by extensive NMR data and mass spectroscopic analysis. Triptotin K showed cytotoxic activities against KB, KBv200, HepG2, and MCF-7/ADM cells lines with IC50 values of 29.88, 36.50, 39.55, and 41.38 μM, respectively.
Graphical Abstract
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was supported by the [Medical Innovation Program of Fujian Provincial Health Commission of China] under [grant number 2017-CX-37]; the [National Natural Science Foundation of China] under [grant number 81202560, 41806173] and the [Natural Science Foundation of Fujian Province of China] under [grant number 2016J01373, 2016Y4005, 2016J01768].