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Natural Product Research
Formerly Natural Product Letters
Volume 34, 2020 - Issue 21
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Research Articles

Inducing secondary metabolite production from Daldinia eschscholzii JC-15 by red ginseng medium

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Pages 3101-3107 | Received 03 Jan 2019, Accepted 07 Apr 2019, Published online: 21 May 2019
 

Abstract

Red ginseng (RG) is one of the most popular herbal medicines and used as a dietary supplement in recent years. The bioactive ingredient in RG can induce the production of novel microbial metabolite from fermented RG. Using the one strain-many compounds strategy, the reinvestigation of the metabolites from Daldinia eschscholzii JC-15 cultured in red ginseng medium led to the isolation of an unprecedented benzopyran-naphthalene hybrid, daldinsin (1) and a new lactone (2). In this research, a new lactone, 8-hydroxylhelicascolide A (2) instead of helicascolide A was produced by the D. eschscholzii JC-15 induced by the red ginseng medium. Compound 1 showed anti-acetylcholinesterase activity with the inhibition ratio of 38.8% at 50 μM. Compound 2 indicated antimicrobial activities against Fusarium Solani, F. oxysporum, and Escherichia coli with MICs at 128 μg/mL. RG is therefore a promising activator in production of novel microbial metabolite.

Graphical Abstract

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

This research work was financially supported by the National Natural Science Foundation of China (81660582, 81560571), and a project of Yunling Scholars of Yunnan Province.

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