Toonamicrocarpavarin, a new tirucallane-type triterpenoid from Toona Ciliata

Abstract

Toonamicrocarpavarin (1), a new tirucallane-type triterpenoid, along with eight known ones, piscidinol A (2), toonaciliatavarin E (3), toonayunnanin A (4), 7-acetyneotrichilenone (5), hispidol A (6), odoratone (7), phellochin (8), toonaciliatavarin D (9), were isolated from T. ciliata. Their structures were identified on the basis of ESIMS, HREIMS and 1 D/2D NMR analysis. The cytotoxic activity of the new compound was also evaluated. All compounds were obtained from T. ciliata for the first time, which plays an important role in chemotaxonomy of the plant T. ciliata.

Graphical Abstract

Keywords:

• Toona ciliata
• toonamicrocarpavarin
• triterpenoid
• cytotoxic activity

Acknowledgments

This work was financially supported by a grant from the Science and Technology Project of Yunnan Province (2019), a grant from Foundational Project of China Tabacco Yunnan Industrial Co., Ltd. (No. 2015CP02), and a grant from Foundation of Yunnan Key Laboratory of Tobacco Chemistry, R&D Center of China Tobacco Yunnan Industrial Co., Ltd. (KCFZ-2017-1096).