New naphthoquinone derivatives from Fusarium napiforme of a mangrove plant

Abstract

Two new naphthoquinone derivatives, 6-hydroxy-astropaquinone B (1) and astropaquinone D (2) as well as the known compound 3-O-methyl-9-O-methylfusarubin (3) were isolated from Fusarium napiforme, an endophytic fungus isolated from the mangrove plant, Rhizophora mucronata. The structures of 1 and 2 were determined by 1D and 2D NMR spectroscopic analyses. Compounds 1, 2 and 3 exhibited moderate antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Furthermore, 1, 2 and 3 were phytotoxic action in lettuce seeding at a concentration of 30 μg · mL⁻¹.

Graphical Abstract

Keywords:

• Endophyte
• naphthoquinone
• 6-hydroxy-astropaquinone B
• astropaquinone D
• antimicrobial activity
• phytotoxicity

Acknowledgements

The authors thank Dr. Takako Aboshi in Yamagata University for MS experimental supports.

Additional information

Funding

This investigation was financially supported by RISTEKDIKTI, Indonesia (World Class Professor Grant, T/83/ D2.3/KK.04.05/2019 by U.S.).