A new dineolignan with anti-β-amyloid aggregation activity from the fruits of crataegus pinnatifida bge

Abstract

A new dineolignan, crataeguslignan A (1), along with one known dineolignan (2) were isolated from the fruits of Crataegus pinnatifida Bge. Its chemical structure was identified by comprehensive spectroscopic analyses. All the isolated compounds were investigated with regard to their Aβ_1–42 inhibition activity. Among them, 1 displayed the most potent Aβ_1–42 inhibitory ability with the inhibition rate of 85.2% at the concentration of 20 μM.

Graphical Abstract

Keywords:

• Crataegus pinnatifida
• dineolignan
• structure elucidation
• Aβ_1‐42 aggregation

Acknowledgments

This work was supported by Career Development Support Plan for Young and Middle-aged Teachers in Shenyang Pharmaceutical University (ZQN2018006) and the Project of Innovation Team Foundation (LT2015027).

Conflict of interest

The authors declare that there is no conflict of interest.

Figure 1. The structure of compound 1.