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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 16
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Research Articles

Isolation and structure determination of new chymotrypsin inhibitory peptides streptopeptolins B and C

Ankit Tiwaria Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka, JapanView further author information
,
Issara Kaweewanb Graduate School of Science and Technology, Shizuoka University, Shizuoka, JapanView further author information
,
Yuto Miyakea Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka, JapanView further author information
,
Hikaru Hemmic Food Research Institute, National Agriculture and Food Research Organization (NARO), Tsukuba, Ibaraki, JapanView further author information
&
Shinya Kodania Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka, Japan;b Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan;d Academic Institute, Shizuoka University, Shizuoka, JapanCorrespondence[email protected]
View further author information
Pages 2700-2706 | Received 16 Jul 2019, Accepted 20 Aug 2019, Published online: 12 Sep 2019
 
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Abstract

New chymotrypsin inhibitory peptides named streptopeptolins B and C were isolated from Streptomyces olivochromogenes. Structures of streptopeptolins B and C were determined to be cyclic depsipeptides possessing 3-amino-6-hydroxy-2-piperidone unit by interpretation of NMR spectra and ESI-MS. Streptopeptolins B and C showed inhibitory activities to chymotrypsin with IC50 of 8.0 and 12.0 μg/mL, respectively.

GRAPHICAL ABSTRACT

Acknowledgments

The NMR spectra were recorded on Bruker Avance 600 and Avance III HD 800 spectrometers at the Advanced Analysis Center, NARO.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was supported by the Japan Society for the Promotion of Science by Grants-in-aids (grant number 16K01913).

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