Abstract
A new epimer of azaphilone derivative pinophilin B, epi-pinophilin B (1), and three known analogues (2–4) were obtained from the culture of the gorgonian-derived fungus Aspergillus fumigatus 14–27. The structures of 1–4, including their relative configurations were determined by extensive spectroscopic analysis and comparing with literature data. The absolute configuration of 1 was determined by electronic circular dichroism (ECD) and optical rotatory (OR) calculations methods. Compounds 1–4 were isolated from A. fumigatus for the first time. Their antibacterial and cytotoxic activities were also evaluated.
Graphical Abstract
![](/cms/asset/2594c937-4495-4d1c-9184-fa2fde8448d1/gnpl_a_1669028_uf0001_c.jpg)
Acknowledgements
We thank all the authors who contributed to this paper.
Disclosure statement
No potential conflict of interest was reported by the authors.